
Three-Dimensional Electron Microscopy of Macromolecular Assemblies
Joachim Frank
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Methods for Three-Dimensional Visualization of Structures in the Cell
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Electron tomography has become a standard technique with applications in cell biology, structural biology, and materials science. This definitive work provides a comprehensive treatment of the mathematical background and working methods of three-dimensional reconstruction from tilt series, with special emphasis on the problems presented by limitations of data collection in the transmission electron microscope.
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